منابع مشابه
Glycine transporter inhibitors as therapeutic agents for schizophrenia.
Multiple lines of evidence suggest that a dysfunction in the glutamatergic neurotransmission via the N-methyl-D-aspartate (NMDA) receptors contributes to the pathophysiology of psychiatric diseases including schizophrenia. The potentiation of NMDA receptor function may be a useful approach for the treatment of diseases associated with NMDA receptor hypofunction. One possible strategy is to incr...
متن کاملGlycine Site Modulators and Glycine Transporter-1 Inhibitors as Novel Therapeutic Targets for the Treatment of Schizophrenia
Current antipsychotic medications are efficacious for the positive symptoms of schizophrenia. However, there remains a significant unmet need for alternate strategies that could result in improved tolerability and/or efficacy for negative and cognitive symptoms. A growing body of research suggests that NMDA mediated neuronal activity is involved in the etiology of schizophrenia. Glycine binds t...
متن کاملZn2+ inhibits glycine transport by glycine transporter subtype 1b.
In the central nervous system, glycine is a co-agonist with glutamate at the N-methyl-D-aspartate subtype of glutamate receptors and also an agonist at inhibitory, strychnine-sensitive glycine receptors. The GLYT1 subtypes of glycine transporters (GLYTs) are responsible for regulation of glycine at excitatory synapses, whereas a combination of GLYT1 and GLYT2 subtypes of glycine transporters ar...
متن کاملPhosphatase inhibitors influence proteolytic cleavage pattern of glycine transporter GlyT2 N-terminus
Calpain activation in spinal cord neurons results in removal of the glycine transporter N-terminal region. In this work we have compared the cleavage patterns of released peptides in presence of both okadaic acid and sodium orthovanadate. Under basal calcium concentration the calpain cleavage patterns are significantly different for these two phosphatase inhibitors. In contrast to one immunopos...
متن کاملSpinal antiallodynia action of glycine transporter inhibitors in neuropathic pain models in mice.
Neuropathic pain is refractory against conventional analgesics, and thus novel medicaments are desired for the treatment. Glycinergic neurons are localized in specific brain regions, including the spinal cord, where they play an important role in the regulation of pain signal transduction. Glycine transporter (GlyT)1, present in glial cells, and GlyT2, located in neurons, play roles in modulati...
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ژورنال
عنوان ژورنال: Archives of Psychiatry Research
سال: 2020
ISSN: 2671-1079,2671-2008
DOI: 10.20471/may.2020.56.01.08